Organocatalysed decarboxylative protonation process from Meldrum's acid: enantioselective synthesis of isoxazolidinones?
Chemical Communications Pub Date: 2013-11-01 DOI: 10.1039/C3CC47695B
Abstract
An asymmetric organocatalysed decarboxylative protonation reaction allowed a straightforward synthesis of α-substituted isoxazolidin-5-ones from readily available 5-substituted Meldrum's acids. This process is initiated by an anionic formal (3+2) cycloaddition–fragmentation, generated in-situ from a sulfone-amide precursor which also served as a latent source of proton.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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