Ready access to 3-amino-2,3-dideoxysugars via regio- and stereo-selective tandem hydroamination–glycosylation of glycals?

Organic & Biomolecular Chemistry Pub Date: 2011-03-02 DOI: 10.1039/C1OB05068K

Abstract

A highly stereoselective BF3·OEt2-promoted tandem hydroamination–glycosylation on a glycal scaffold has been developed to form 3-amino-2,3-dideoxysugars in a one-pot procedure. This efficient multicomponent reaction protocol offers simplicity and general applicability to a broad range of variations on each component.

Graphical abstract: Ready access to 3-amino-2,3-dideoxysugars via regio- and stereo-selective tandem hydroamination–glycosylation of glycals
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