Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions?
Green Chemistry Pub Date: 2016-07-14 DOI: 10.1039/C6GC01601D
Abstract
A novel, rapid and efficient route to imidazo[1,2-a]pyridines under ambient, aqueous and metal-free conditions is reported. The NaOH-promoted cycloisomerisations of N-propargylpyridiniums give quantitative yield in a few minutes (10 g scale). A comparison of common green metrics to current routes showed clear improvements, with at least a one order of magnitude increase in space-time-yield.
![Graphical abstract: Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions](http://scimg.chem960.com/usr/1/C6GC01601D.jpg)
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Journal Name：Green Chemistry
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