Rh(iii)-catalyzed chemoselective C–H functionalizations of tertiary aniline N-oxides with alkynes?

Chemical Communications Pub Date: 2016-04-05 DOI: 10.1039/C6CC02217K

Abstract

In this work, we report novel Rh(III)-catalyzed chemoselective functionalizations of tertiary aniline N-oxides with alkynes, including annulation via the sequential C(sp2)–H and C(sp3)–N activation for the formation of N-alkylindoles and an O-atom transfer (OAT) process for the synthesis of acetophenones.

Graphical abstract: Rh(iii)-catalyzed chemoselective C–H functionalizations of tertiary aniline N-oxides with alkynes
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