Rh(ii)-catalyzed branch-selective C–H alkylation of aryl sulfonamides with vinylsilanes?
Chemical Science Pub Date: 2019-11-11 DOI: 10.1039/C9SC04308J
Abstract
Rhodium(II)-catalyzed unusual branch-selective ortho-C–H alkylation of aryl sulfonamides with vinylsilanes was achieved using an 8-aminoquinoline directing group. Notably, the para-substituted aryl sulfonamides gave mono-(branched)alkylated products exclusively without the formation of any double C–H alkylated byproducts. The results of deuterium labeling experiments suggest that both hydrometalation and carbometalation pathways are involved in this conversion.
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Journal Name：Chemical Science
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CAS no.: 89640-58-4
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