Nucleophilic fluorination facilitated by a CsF–CaF2 packed bed reactor in continuous flow?
Chemical Communications Pub Date: 2018-01-02 DOI: 10.1039/C7CC09035H
Abstract
A simple to prepare, dry and handle packed bed reactor carrying CsF on CaF2, towards nucleophilic fluorinations in continuous flow, is reported. The reactor also proved adaptable for silyl-ether deprotection and trifluoromethylations with Ruppert's reagent. The study includes reactor stability and scale-up investigations.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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