Quantitative tracking of endoplasmic reticulum viscosity during ferroptosis by an iridium complex via TPPLM?
Chemical Communications Pub Date: 2021-04-21 DOI: 10.1039/D1CC01062J
Abstract
Herein, we report a neutral iridium complex, [Ir(4-(2-pyridinyl)benzaldehyde)2(acetylacetone)] (Ir-ER), with viscosity-responsive phosphorescent emission intensity and lifetime. Quantitative measurement by two-photon phosphorescent lifetime imaging shows that the viscosity of ER increases significantly in the process of erastin-induced ferroptosis. Our work provides an effective strategy for quantitative measurement of the micro-environmental alternations of subcellular organelles during a specific cell death process.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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