A simple and rapid approach for testing enantiopurity of hydroxy acids and their derivatives using 1H NMR spectroscopy?

RSC Advances Pub Date: 2015-07-30 DOI: 10.1039/C5RA11919G

Abstract

A rapid and the simple chiral derivatizing protocol involving the coupling of 2-formylphenylboronic acid and an optically pure [1,1-binaphthalene]-2,2-diamine is introduced for the accurate determination of the enantiopurity of hydroxy acids and their derivatives, possessing one or two optically active centers, using 1H NMR spectroscopy.

Graphical abstract: A simple and rapid approach for testing enantiopurity of hydroxy acids and their derivatives using 1H NMR spectroscopy
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