One pot synthesis of α-ketoamides from ethylarenes and amines: a metal free difunctionalization strategy?
Organic & Biomolecular Chemistry Pub Date: 2016-11-17 DOI: 10.1039/C6OB02361D
Abstract
One-pot and metal free synthesis of α-ketoamides has been described through in situ generation of aryl ketones from easily available ethylarenes followed by amidation with various amines. This multiple oxidation protocol involves catalytic I2–pyridine–TBHP (t-butyl hydroperoxide) mediated oxidative benzylic carbonylation and sequential NaI–TBHP mediated oxidative amidation without using any solvent.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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