Self-immolative systems for the disclosure of reactive electrophilic alkylating agents?

Chemical Communications Pub Date: 2019-04-04 DOI: 10.1039/C8CC09728C

Abstract

In this paper we report the design, synthesis and assessment of the first examples of self-immolative systems triggered by non-acidic electrophilic agents such as methyl, allyl or benzylic halides. These systems provide a visual colorimetric disclosure response upon exposure to these electrophilic reagents under mild, basic conditions without the need for the use of analytical instrumentation.

Graphical abstract: Self-immolative systems for the disclosure of reactive electrophilic alkylating agents
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