Renal-specific delivery of prednisolone-folate conjugates for renal ischemia/reperfusion injury?

RSC Advances Pub Date: 2014-10-03 DOI: 10.1039/C4RA11160E

Abstract

Prednisolone-folate conjugate (PFC) was synthesized to achieve renal-targeted delivery and specific intracellular release of prednisolone. Our results highlight the significance of folate-mediated targeted delivery to the kidney and the consequent in vivo therapeutic efficacy of PFC against renal ischemia/reperfusion injury.

Graphical abstract: Renal-specific delivery of prednisolone-folate conjugates for renal ischemia/reperfusion injury
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