A trifluoromethylphenyl diazirine-based SecinH3 photoaffinity probe?

Chemical Communications Pub Date: 2011-11-28 DOI: 10.1039/C2CC16477A

Abstract

The synthesis of a trifluoromethylphenyl diazirine photoaffinity probe of the cytohesin inhibitor SecinH3 is described. The probe exhibits improved labelling efficiency over a benzophenone-based probe and thus is more suitable for photoaffinity labelling in complex biological samples.

Graphical abstract: A trifluoromethylphenyl diazirine-based SecinH3 photoaffinity probe
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