Regioselective C–H chlorination: towards the sequential difunctionalization of phenol derivatives and late-stage chlorination of bioactive compounds?
RSC Advances Pub Date: 2017-10-03 DOI: 10.1039/C7RA09939H
Abstract
We have developed a protocol for the auxillary directed C–H chlorination of phenol derivatives using catalytic amounts of palladium acetate that is amenable to the late-stage chlorination of diflufenican and estrone. The 2-pyridine group allows for a highly efficient palladium-catalyzed chlorination and sequential ortho C–H functionalization reaction of phenol derivatives to produce a variety of symmetrical and unsymmetrical 2,4,6-trisubstituted phenols.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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