Selective palladium-catalysed arylation of 2,6-dibromopyridine using N-heterocyclic carbene ligands?

RSC Advances Pub Date: 2015-06-10 DOI: 10.1039/C5RA10561G

Abstract

A selective palladium-catalysed arylation of 2,6-dibromopyridine has been developed by employing N-heterocyclic carbene ligands. Selective mono-arylation was performed in water/acetonitrile solvent system at ambient temperature with catalyst loading of 0.1 mol%. This reaction was also found to proceed smoothly in water although at a slightly elevated temperature of 80 °C. 2,6-Disubstituted and diversely substituted 2,6-pyridines were also obtained in high yields which will be of importance to organic and medicinal chemists.

Graphical abstract: Selective palladium-catalysed arylation of 2,6-dibromopyridine using N-heterocyclic carbene ligands
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