Pericosines, antitumour metabolites from the sea hare-derived fungus Periconia byssoides. Structures and biological activities?
Organic & Biomolecular Chemistry Pub Date: 2007-10-26 DOI: 10.1039/B713060K
Abstract
Pericosines A–E 1–5 have been isolated from a strain of Periconia byssoides originally separated from the sea hare Aplysia kurodai. Among them, pericosines C 3 and E 5 were separated as enantiomeric mixtures. Their stereostructures, except for compound 1, have been elucidated or identified on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, and X-ray analysis. In addition, conformation for all the compounds has been discussed. Compounds 1–3 exhibited significant growth inhibition against tumour cell lines. Pericosine A 1 also showed significant in vivo tumour inhibitory activity. In addition, compound 1 inhibited the
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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