Proline-based reduced dipeptides as recyclable and highly enantioselective organocatalysts for asymmetric Michael addition?

Organic & Biomolecular Chemistry Pub Date: 2011-07-21 DOI: 10.1039/C1OB05679D

Abstract

A series of novel proline-based reduced dipeptides was developed and evaluated for a direct Michael addition of ketones and aldehydes to nitroalkenes. Excellent yields (up to 95%), diastereoselectivities (up to 98% dr) and enantioselectivities (up to 98% ee) were achieved in the presence of 5 mol% catalyst without any additional additives at room temperature.

Graphical abstract: Proline-based reduced dipeptides as recyclable and highly enantioselective organocatalysts for asymmetric Michael addition
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