Nickel-catalyzed ortho-halogenation of unactivated (hetero)aryl C–H bonds with lithium halides using a removable auxiliary?
Chemical Communications Pub Date: 2016-03-09 DOI: 10.1039/C6CC00822D
Abstract
The first example of Ni-catalyzed halogenation of (hetero)aryl C–H bonds with lithium halides (LiX, X = Br, I, Cl) using PIP as a removable directing group is reported. This protocol provides an efficient access to ortho-halogenated (hetero)arenes with operational simplicity, good functional group tolerance, and large-scale synthesis.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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