Nickel-catalyzed monofluoromethylation of (hetero)aryl bromides via reductive cross-coupling?
Chemical Communications Pub Date: 2019-06-07 DOI: 10.1039/C9CC03737C
Abstract
A mild and efficient nickel-catalyzed direct monofluoromethylation of (hetero)aryl bromides by reductive cross-coupling has been developed. This method exhibits good efficiency, wide functional-group compatibility, and suitability for aryl and heteroaryl bromides with abundant industrial raw material BrCH2F. This strategy provides an efficient way to synthesize monofluoromethylated molecules for drug discovery.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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