Pd/tetraphosphine catalytic system for Cu-free Sonogashira reaction “on water”?
Catalysis Science & Technology Pub Date: 2013-11-22 DOI: 10.1039/C3CY00831B
Abstract
An efficient copper-free Sonogashira coupling reaction was performed on water at 100 °C with N,N,N′,N′-tetra(diphenylphosphinomethyl)pyridine-2,6-diamine (1) as a ligand, [Pd(η3-C3H5)Cl]2 as a catalyst precursor and K3PO4 as a base. Both aryl and heteroaryl halides were successfully alkynylated in this system, and a high turnover number (TON) up to 860?000 was obtained with a catalyst loading as low as 1 ppm.
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Journal Name：Catalysis Science & Technology
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CAS no.: 89640-58-4
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