Recent advances in the synthesis of ent-kaurane diterpenoids
Natural Product Reports Pub Date: 2021-07-15 DOI: 10.1039/D1NP00028D
Abstract
Covering: 2015 to 2020
The ent-kaurane diterpenoids are integral parts of tetracyclic natural products that are widely distributed in terrestrial plants. These compounds have been found to possess interesting bioactivities, ranging from antitumor, antifungal and antibacterial to anti-inflammatory activities. Structurally, the different tetracyclic moieties of ent-kauranes can be seen as the results of intramolecular cyclizations, oxidations, C–C bond cleavages, degradation, or rearrangements, starting from their parent skeleton. During the past decade, great efforts have been made to develop novel strategies for synthesizing these natural products. The purpose of this review is to describe the recent advances in the total synthesis of ent-kaurane diterpenoids covering the period from 2015 to date.
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Journal Name：Natural Product Reports
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CAS no.: 89640-58-4
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