Pressurized CO2 as a carboxylating agent for the biocatalytic ortho-carboxylation of resorcinol?
Green Chemistry Pub Date: 2018-04-03 DOI: 10.1039/C8GC00008E
Abstract
The utilization of gaseous carbon dioxide instead of bicarbonate would greatly facilitate process development for enzyme catalyzed carboxylations on a large scale. As a proof-of-concept, 1,3-dihydroxybenzene (resorcinol) was carboxylated in the ortho-position using pressurized CO2 (～30–40 bar) catalyzed by ortho-benzoic acid decarboxylases with up to 68% conversion. Optimization studies revealed tight pH-control and enzyme stability as the most important determinants.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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