Reactivity of bromofluorenes in palladium-catalysed direct arylation of heteroaromatics
Catalysis Science & Technology Pub Date: 2014-07-30 DOI: 10.1039/C4CY00771A
Abstract
The palladium-catalysed direct arylation using bromofluorenes and heteroaromatics as the coupling partners proceeded in moderate to high yields using only 0.1–0.5 mol% Pd(OAc)2 or 1 mol% PdCl(C3H5)(dppb) as the catalyst and KOAc as the base. A wide variety of heteroarenes have been successfully employed, allowing their properties to be easily tuned. From 2,7-dibromofluorene, successive arylations allow the introduction of two different heteroarenes at carbons C2 and C7.
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Journal Name：Catalysis Science & Technology
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CAS no.: 89640-58-4
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