Palladium-catalyzed dicarbonylative synthesis of tetracycle quinazolinones?

Organic & Biomolecular Chemistry Pub Date: 2015-03-12 DOI: 10.1039/C5OB00368G

Abstract

An interesting procedure for the synthesis of isoindolo[1,2-b]quinazolin-10(12H)-ones has been developed. Starting from commercially available 2-bromoanilines and 2-bromobenzyl amines, with the assistance of a palladium catalyst, the desired products were isolated in good yields. Notably, this procedure proceeded in a highly selective manner; two molecules of CO were incorporated into the substrates selectively.

Graphical abstract: Palladium-catalyzed dicarbonylative synthesis of tetracycle quinazolinones
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