Preparation of modified peptides: direct conversion of α-amino acids into β-amino aldehydes??

Organic & Biomolecular Chemistry Pub Date: 2012-04-20 DOI: 10.1039/C2OB25433F

Abstract

A direct method for the transformation of α-amino acids into β-amino aldehydes was developed, and applied to the modification of the C-terminal residue of peptides. The method takes place in good yields and under mild conditions. The application of this methodology to the preparation of small peptides with γ-amino alcohol units, which are precursors of analogues of peptaibol antibiotics, is also described.

Graphical abstract: Preparation of modified peptides: direct conversion of α-amino acids into β-amino aldehydes
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