New conjugates of β-cyclodextrin with manganese(iii) salophen and porphyrin complexes as antioxidant systems?

Dalton Transactions Pub Date: 2011-02-14 DOI: 10.1039/C0DT01480J

Abstract

Oxidative stress is the hallmark of several pathologies like arthritis, hypertension and many neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. In this scenario, antioxidant compounds can play a pivotal role in treating these severe pathologies. The synthesis of molecules able to mimic physiologically-relevant proteins is nowadays of particular interest. Several transition metal complexes, especially manganese(III) complexes with porphyrin and salen-type ligands, have been reported to be superoxide scavengers. Here we report the synthesis and spectroscopic characterization of manganese(III) complexes of 5[4-(6-O-β-cyclodextrin)-phenyl],10,15,20-tri(4-hydroxyphenyl)-porphyrin and of 6A-deoxy-6A[(S-cysteamidobenzoyl(3,4-diamino)-N,N′-bis(salicylidene))]-β-cyclodextrin. The superoxide dismutase activity of the metal complexes was investigated by indirect methods. The catalase and peroxidase activities were tested using ABTS assays.

Graphical abstract: New conjugates of β-cyclodextrin with manganese(iii) salophen and porphyrin complexes as antioxidant systems
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