Organocatalytic asymmetric chlorinative dearomatization of naphthols?
Chemical Science Pub Date: 2015-04-27 DOI: 10.1039/C5SC00494B
Abstract
An organocatalytic asymmetric chlorinative dearomatization of naphthols was realized for the first time, providing chiral naphthalenones with a Cl-containing all-substituted stereocenter in excellent yields and enantioselectivity (up to 97% yield and 96% ee). The reaction features mild reaction conditions, good tolerance of diverse functional groups and simple reaction operation.
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Journal Name：Chemical Science
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CAS no.: 89640-58-4
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