Quinoxaline derivatives disrupt the base stacking of hepatitis C virus-internal ribosome entry site RNA: reduce translation and replication?
Chemical Communications Pub Date: 2019-10-15 DOI: 10.1039/C9CC06531H
Abstract
RNA-biased small molecules with a monoquinoxaline core target the L-shaped structure of subdomain IIa of Hepatitis C virus internal ribosome entry site (IRES) RNA in proximity to the Mg2+ binding site. The binding event leads to the destacking of RNA bases, resulting in the inhibition of IRES-mediated translation and HCV RNA replication.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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