Polymyxin-based photosensitizer for the potent and selective killing of Gram-negative bacteria?

Chemical Communications Pub Date: 2020-02-26 DOI: 10.1039/D0CC00155D

Abstract

Here we report the synthesis of a novel methylene blue-polymyxin conjugate and demonstrate its light-mediated killing of Gram-negative bacteria on skin models of infection demonstrating a 108 decrease in bacterial colony-forming units.

Graphical abstract: Polymyxin-based photosensitizer for the potent and selective killing of Gram-negative bacteria
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