Optimisation of BACE1 inhibition of tripartite structures by modification of membrane anchors, spacers and pharmacophores – development of potential agents for the treatment of Alzheimer's disease?
Organic & Biomolecular Chemistry Pub Date: 2012-08-03 DOI: 10.1039/C2OB26103K
Abstract
Systematic variation of membrane anchor, spacer and pharmacophore building blocks leads to an optimisation of the inhibitory effect of tripartite structures towards BACE1-induced cleavage of the amyloid precursor protein (APP).
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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