Poly(N-(2-hydroxypropyl)methacrylamide)–valproic acid conjugates as block copolymer nanocarriers?
Polymer Chemistry Pub Date: 2017-02-22 DOI: 10.1039/C7PY00196G
Abstract
We report nanoassemblies based on block copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) in which drug cleavage enhances the biological compatibility of the original polymer carrier by regeneration of HPMA units. Drug release via ester hydrolysis suggests this approach offers potential for stimuli-responsive drug delivery under acidic conditions.
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Journal Name：Polymer Chemistry
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CAS no.: 89640-58-4
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