Protecting group free synthesis of urea-linked glycoconjugates: efficient synthesis of β-urea glycosides in aqueous solution?
Organic & Biomolecular Chemistry Pub Date: 2014-05-02 DOI: 10.1039/C3OB42452A
Abstract
A method for the protecting group free synthesis of β-urea-linked glycoconjugates has been developed. The one step process, involving reactions between urea and D-glucose, N-acetyl-D-glucosamine or D-xylose in acidic aqueous solution, furnishes the corresponding β-urea glycosides in modest yields. This simple and efficient procedure is applicable to the synthesis of β-urea tethered amino acid–carbohydrate conjugates.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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