Reduction of a platinum(iv) prodrug model by sulfur containing biological reductants: computational mechanistic elucidation?
Chemical Communications Pub Date: 2018-08-20 DOI: 10.1039/C8CC05682J
Abstract
A PtIV prodrug needs to be reduced to PtII by a biomolecule in order to show efficacy. Among biomolecules, those containing an L-Cys residue have the highest potential to be involved in reduction. Tautomerisation from HSCH2CH(NH3+)CO2? to the unusual zwitterion form ?SCH2CH(NH3+)CO2H is the prerequisite for L-Cys to become a potent reductant at a low pH.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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