Negishi coupling reactions as a valuable tool for [11C]methyl-arene formation; first proof of principle?
Chemical Communications Pub Date: 2013-10-18 DOI: 10.1039/C3CC47203E
Abstract
The Negishi coupling reaction between arylzinc halide reagents and 11CH3I has been used to synthesise 11C-methylated arene species via a palladium-mediated process. The metabotropic glutamate receptor subtype-5 radiotracer [11C]MPEP has been radiolabelled using this technique.
![Graphical abstract: Negishi coupling reactions as a valuable tool for [11C]methyl-arene formation; first proof of principle](http://scimg.chem960.com/usr/1/C3CC47203E.jpg)
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Journal Name：Chemical Communications
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