Preparation of fluoroalkoxy or fluorophenoxy substituted N-heterocycles from heterocyclic N-oxides and polyfluoroalcohols?
Organic Chemistry Frontiers Pub Date: 2018-06-21 DOI: 10.1039/C8QO00499D
Abstract
A novel and efficient approach to introduce fluorine-containing groups into N-heterocycles was reported. In this work, appropriate polyfluoroalcohols were used as the fluorine source, PyBroP as the activating agent, DCE as the solvent and silver carbonate as the base. The obvious advantage of the process is that the fluorination compounds were produced in moderate to good yields and with excellent regioselectivity in most cases. Moreover, this reaction also features remarkable functional group compatibility and broad substrate scope.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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