Photodelivery of β-phenylethylamines?

Organic & Biomolecular Chemistry Pub Date: 2020-09-21 DOI: 10.1039/D0OB01792B

Abstract

We have developed the first photodonors for the trace amino neurotransmitters, β-phenylethylamine (DPSY1) and β-methylphenylethylamine (DPSY2). Our photodonors react rapidly with photosensitized singlet dioxygen (1O2) to yield the amines. The photodelivery of β-phenylethylamine into aqueous solutions by employing liposome scaffolds is successfully demonstrated.

Graphical abstract: Photodelivery of β-phenylethylamines
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