Multi-stimuli controlled release of a transmembrane chloride ion carrier from a sulfonium-linked procarrier?

Organic & Biomolecular Chemistry Pub Date: 2020-10-28 DOI: 10.1039/D0OB00938E

Abstract

In recent times, anion transporters have received substantial consideration due to their ability to disrupt the ionic equilibrium across membrane bilayers. While numerous Cl? ion transporters were developed for channelopathies, unfortunately, poor aqueous solubility precluded their bioapplicability. Herein, we demonstrate the development of a multi-stimuli activatable anion transport approach to induce regulated transport of Cl? ions across membranes under specific conditions. The sulfonium-based procarrier was initially inactive, but the transmembrane transport of Cl? ions was activated in the presence of stimuli such as glutathione (GSH), reactive oxygen species (ROS) and light. The release of the hydrophobic anionophore from the aqueous-soluble procarrier under specific conditions leads to the successful transport of Cl? ions. Under physiological conditions, these anion carriers follow an antiport exchange mechanism to transport Cl? ions across lipid bilayers. Such multi-stimuli activatable procarriers have great potential to combat various types of channelopathies, including cancer, cystic fibrosis, kidney stones, myotonia, and others.

Graphical abstract: Multi-stimuli controlled release of a transmembrane chloride ion carrier from a sulfonium-linked procarrier
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