Oligo- and poly-nucleotides: 50 years of chemical synthesis

Organic & Biomolecular Chemistry Pub Date: 2005-10-05 DOI: 10.1039/B510458K

Abstract

It is fifty years since the first chemical synthesis of a dinucleoside phosphate and a dinucleotide with natural 3′→5′-internucleotide linkages was reported. The main developments in the methodology of oligo- and poly-nucleotide synthesis that have taken place since are described.

Graphical abstract: Oligo- and poly-nucleotides: 50 years of chemical synthesis
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