Radical perfluoroalkylation – easy access to 2-perfluoroalkylindol-3-imines via electron catalysis?
Chemical Communications Pub Date: 2016-03-31 DOI: 10.1039/C6CC02284G
Abstract
Arylisonitriles (2 equivalents) react with alkyl and perfluoroalkyl radicals to form 2-alkylated indole-3-imines via two sequential additions to the isonitrile moiety followed by homolytic aromatic substitution. The three component reaction comprises three C–C bond formations. The endocyclic imine functionality in the products is more reactive in follow up chemistry and hydrolysis of the exocyclic imine leads to 3-oxindoles that show fluorescence properties.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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