Palladium-catalyzed direct alkenylation of 4-hydroxy-2-pyridones?
RSC Advances Pub Date: 2016-01-12 DOI: 10.1039/C5RA26360C
Abstract
The first direct C-3 alkenylation of N-substituted-4-hydroxy-2-pyridones with unactivated alkenes has been achieved under conventional palladium acetate catalysis. The presented protocol enables the efficient production of functionalized furo[3,2-c]-pyridones-2 when terminal alkenes are utilized and 3-alkenyl-4-hydroxy-2-pyridones when more substituted reaction partners are involved. The mild reaction conditions allow easy, scalable access to pyridone derivatives that resemble core structures isolated from natural alkaloids.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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