Palladium-catalyzed cross-coupling reaction of alkenyl aluminums with 2-bromobenzo[b]furans?

RSC Advances Pub Date: 2020-05-22 DOI: 10.1039/D0RA02984J

Abstract

Highly efficient and simple cross-coupling reactions of 2-bromobenzo[b]furans with alkenylaluminum reagents for the synthesis of 2-alkenylbenzo[b]furan derivatives using PdCl2 (3 mol%)/XantPhos (6 mol%) as catalyst are reported. Excellent yields (up to 97%) were obtained for a wide range of substrates at 80 °C for 4 h in DCE.

Graphical abstract: Palladium-catalyzed cross-coupling reaction of alkenyl aluminums with 2-bromobenzo[b]furans
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