Organocatalyzed coupling of indoles with dehydroalanine esters: synthesis of bis(indolyl)propanoates and indolacrylates

RSC Advances Pub Date: 2013-08-08 DOI: 10.1039/C3RA42922A

Abstract

Functionalized and substituted bis(indolyl)alkanes were synthesized from indoles and dehydroalanine esters in the presence of catalytic amounts of Br?nsted acid. When 2- or 4-bulky substituted indoles were used, unusual elimination occurred to yield interesting indolyl acrylates.

Graphical abstract: Organocatalyzed coupling of indoles with dehydroalanine esters: synthesis of bis(indolyl)propanoates and indolacrylates
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