Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions?
Chemical Communications Pub Date: 2018-06-25 DOI: 10.1039/C8CC01360H
Abstract
The on-column functionalization of oligodeoxynucleotides via base-free Suzuki cross-coupling reactions is reported herein. These cross-coupling reactions were carried out with various boronic acids and either full-length modified oligonucleotides containing one or more 2′-deoxy-5-iodouridine (5IdU) monomer(s) or on oligonucleotide fragments immediately after incorporation of 5IdU. Five different functionalities were coupled to oligonucleotides containing one or three attachment points.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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