One-pot three component synthesis of 5-allyl-1,2,3-triazoles using copper(i) acetylides?
RSC Advances Pub Date: 2018-01-12 DOI: 10.1039/C7RA12889D
Abstract
One-pot three-component reactions using copper(I) acetylide, azide, allyl iodide, and NaOH have been developed. The reactions proceed smoothly at room temperature to afford 5-allyl-1,2,3-triazoles, which can be further transformed into a variety of 1,2,3-triazole-fused bi-/tricyclic scaffolds. This method offers the most efficient, convenient, and practical route towards useful polycyclic scaffolds in moderate to excellent yields.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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