Mild electrophilic trifluoromethylthiolation of ketones with trifluoromethanesulfanamide?
Organic & Biomolecular Chemistry Pub Date: 2015-05-14 DOI: 10.1039/C5OB00960J
Abstract
A straightforward and convenient approach for trifluoromethylthiolation of various acyclic and cyclic ketones with PhNHSCF3 is described. The reaction proceeds smoothly in the presence of acetyl chloride at room temperature and affords α-trifluoromethylthiolated ketones in fair to good yields.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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