One-pot preparation of trifluoromethylated homoallylic N-acylhydrazines or α-methylene-γ-lactams from acylhydrazines, trifluoroacetaldehyde methyl hemiacetal, allyl bromide and tin?
Organic & Biomolecular Chemistry Pub Date: 2015-12-15 DOI: 10.1039/C5OB02260F
Abstract
An efficient and convenient one-pot method for the preparation of trifluoromethylated homoallylic N-acylhydrazines or α-methylene-γ-lactams has been described. In this process, allyl bromide and metal tin are used instead of toxic stannanes, and commercially available aqueous trifluoroacetaldehyde methyl hemiacetal was used as a trifluoromethyl source.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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