Mitochondria-targeting phosphorescent iridium(iii) complexes for living cell imaging?

Dalton Transactions Pub Date: 2014-09-15 DOI: 10.1039/C4DT00823E

Abstract

Two phosphorescent iridium(III) complexes conjugated to a lipophilic triphenylphosphonium cation moiety, IrMitoOlivine and IrMitoNIR, were synthesized. The complexes show high mitochondria-specificity and relatively lower cytotoxicity. Time-lapse confocal imaging indicates that both complexes exhibit an excellent anti-photobleaching capability under continuous laser irradiation.

Graphical abstract: Mitochondria-targeting phosphorescent iridium(iii) complexes for living cell imaging
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