A regioselective synthesis of the dephospho ditholene protected molybdopterin?

RSC Advances Pub Date: 2014-04-11 DOI: 10.1039/C4RA02786H

Abstract

The molybdopterin (MPT) is a complex molecule, made out of three distinctly different components. A retrosynthetic analysis provides a possible route for its synthesis that utilizes the coupling of a diamine with an osone analog. A regioselective condensation of the diamine with an osone affords the dephospho MPT, which has been characterized by NMR and IR spectroscopies, as well as high-resolution mass spectrometry.

Graphical abstract: A regioselective synthesis of the dephospho ditholene protected molybdopterin
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