NCS-promoted thiocyanation and selenocyanation of pyrrolo[1,2-a]quinoxalines?
Organic & Biomolecular Chemistry Pub Date: 2020-10-27 DOI: 10.1039/D0OB01818J
Abstract
An efficient NCS-promoted thiocyanation of pyrrolo[1,2-a]quinoxalines with NH4SCN or KSCN is described. A series of diverse 1-thiocyanatopyrrolo[1,2-a]quinoxalines were obtained in good yields with excellent functional group tolerance. With a similar strategy, the selenocyanation of pyrrolo[1,2-a]quinoxalines with KSeCN is also achieved. Importantly, this approach features mild reaction conditions, broad substrate scope, and gram-scale synthesis. Moreover, the transformations of the products are also further examined.
![Graphical abstract: NCS-promoted thiocyanation and selenocyanation of pyrrolo[1,2-a]quinoxalines](http://scimg.chem960.com/usr/1/D0OB01818J.jpg)
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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