Metal-free regioselective direct thiolation of 2-pyridones?
Organic & Biomolecular Chemistry Pub Date: 2019-06-14 DOI: 10.1039/C9OB01061K
Abstract
A highly regioselective metal-free direct C–H thiolation of 2-pyridones with disulfides or thiols has been developed. A combination of persulfate and a commercially available halide source such as LiCl, NCS or I2 enables the successful direct incorporation of a sulfide moiety into the 5-position of pyridone under mild conditions, providing a useful and convenient approach for the preparation of a diverse array of 5-thio-substituted pyridones in moderate to excellent yields.
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Journal Name：Organic & Biomolecular Chemistry
research_products
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CAS no.: 89640-58-4
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