Metal free C–H functionalization of diazines and related heteroarenes with organoboron species and its application in the synthesis of a CDK inhibitor, meriolin 1?
Organic & Biomolecular Chemistry Pub Date: 2016-04-18 DOI: 10.1039/C6OB00526H
Abstract
Here, we report a metal-free cross-coupling reaction of diazines and related heteroarenes with organoboron species via C–H functionalization. The optimized conditions represent a metal-free method for the activation of aryl/heteroarylboronic acids, which undergo coupling with diazines and related heteroarenes. Optimized conditions also find application in the synthesis of a pyrimidine-based potent CDK inhibitor, meriolin1.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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